English | 2012 | 191 Pages | ISBN: 1849733643 | PDF | 3.8 MB
Nuclear receptors (NR) are ligand induced activated transcription factors involved in numerous biological processes. This book provides a state of the art review on investigations into modeling nuclear receptors looking at the strengths, weaknesses and limitations of the approaches described. The contents include an introduction to their structure and function, a critical overview of experimental structural data as a base for modeling, the latest in the development of theoretical approaches to nuclear receptors modeling, computational studies of nuclear receptors to predict interactions with small ligands, in vitro and in vivo experiments to validate computational simulations, experimental applications and case studies, and nuclear receptors as targets for endocrine disruptor screening.
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